The 2011 International Consumer Electronics Show in Las Vegas will mark Nintendo's first appearance at CES for 16 years.
Nintendo's upcoming 3DS handheld, due for a 2011 release, is expected to play a large part in the console giant's presence at the January show.
The company last appeared at CES in 1994, demonstrating prototype graphics hardware for what eventually became the Nintendo 64.
Also in attendance will be rivals Sony and Microsoft, as well as PC gaming component firms such as AMD and Intel.
"With the gaming market expected to generate $20.3 million in 2010, the International CES is the must-stop hub for innovative gaming products, and will allow CES attendees to experience the future of gaming from an amazing range of innovative companies," said Karen Chupka, senior vice president, events and conferences, CEA.