M64Py is a Qt4 front-end (GUI) for Mupen64Plus 2.0, a cross-platform plugin-based Nintendo 64 emulator. Front-end is written in Python and it provides a user-friendly interface over Mupen64Plus shared library.
Quote: Features
ROMs list with preview images
Input bindings configuration
Cheats support
Support gzip, bzip2, zip, rar and 7z archives
Video extension (experimental)