Retaining the core principle of the original arcade classic, you'll control giant chimps and Godzilla-like creations as they stomp on cities and buildings.
We remember Rampage being most fun in multiplayer, and Total Destruction will boast a four-player mode that allows gamers to either co-operate or battle in seven urban environments.
It's not the most anticipated game coming to Wii, but it'll be a laugh with four players all going for it. These new screens show some huge bosses in action too.
At the time of writing, Midway was unavailable to comment on how the game will take advantage of Wii's unique controller, and a release date is yet to be confirmed. We'll shout at them every day until they give us the info.